If statins don’t work in the long run, then what can you do to protect your heart from atherosclerosis? My personal opinion is that you need to focus on natural ways to reduce the number of small dense LDL particles, which feed the plaque, and alternative ways to supply the product that the plaque produces (more about that in a moment). Obviously, you need to cut way back on fructose intake, and this means mainly eating whole foods instead of processed foods. With less fructose, the liver won’t have to produce as many LDL particles from the supply side. From the demand side, you can reduce your body’s dependency on both glucose and fat as fuel by simply eating foods that are good sources of lactate. Sour cream and yogurt contain lots of lactate, and milk products in general contain the precursor lactose, which gut bacteria will convert to lactate, assuming you don’t have lactose intolerance. Strenuous physical exercise, such as a tread machine workout, will help to get rid of any excess fructose and glucose in the blood, with the skeletal muscles converting them to the much coveted lactate.
Finally, I have a set of perhaps surprising recommendations that are based on research I have done leading to the two papers that are currently under review (Seneff3 et al, Seneff4 et al.). My research has uncovered compelling evidence that the nutrient that is most crucially needed to protect the heart from atherosclerosis is cholesterol sulfate. The extensive literature review my colleagues and I have conducted to produce these two papers shows compellingly that the fatty deposits that build-up in the artery walls leading to the heart exist mainly for the purpose of extracting cholesterol from glycated small dense LDL particles and synthesizing cholesterol sulfate from it, providing the cholesterol sulfate directly to the heart muscle. The reason the plaque build-up occurs preferentially in the arteries leading to the heart is so that the heart muscle can be assured an adequate supply of cholesterol sulfate. In our papers, we develop the argument that the cholesterol sulfate plays an essential role in the caveolae in the lipid rafts, in mediating oxygen and glucose transport.
The skin produces cholesterol sulfate in large quantities when it is exposed to sunlight. Our theory suggests that the skin actually synthesizes sulfate from sulfide, capturing energy from sunlight in the form of the sulfate molecule, thus acting as a solar-powered battery. The sulfate is then shipped to all the cells of the body, carried on the back of the cholesterol molecule.
Evidence of the benefits of sun exposure to the heart is compelling, as evidenced by a study conducted to investigate the relationship between geography and cardiovascular disease (Grimes et al., 1996). Through population statistics, the study showed a consistent and striking inverse linear relationship between cardiovascular deaths and estimated sunlight exposure, taking into account percentage of sunny days as well as latitude and altitude effects. For instance, the cardiovascular-related death rate for men between the ages of 55 and 64 was 761 in Belfast, Ireland but only 175 in Toulouse, France.
Cholesterol sulfate is very versatile. It is water soluble so it can travel freely in the blood stream, and it enters cell membranes ten times as readily as cholesterol, so it can easily resupply cholesterol to cells. The skeletal and heart muscle cells make good use of the sulfate as well, converting it back to sulfide, and synthesizing ATP in the process, thus recovering the energy from sunlight. This decreases the burden on the mitochondria to produce energy. The oxygen released from the sulfate molecule is a safe source of oxygen for the citric oxide cycle in the mitochondria.
So, in my view, the best way to avoid heart disease is to assure an abundance of an alternative supply of cholesterol sulfate. First of all, this means eating foods that are rich in both cholesterol and sulfur. Eggs are an optimal food, as they are well supplied with both of these nutrients. But secondly, this means making sure you get plenty of sun exposure to the skin. This idea flies in the face of the advice from medical experts in the United States to avoid the sun for fear of skin cancer. I believe that the excessive use of sunscreen has contributed significantly, along with excess fructose consumption, to the current epidemic in heart disease. And the natural tan that develops upon sun exposure offers far better protection from skin cancer than the chemicals in sunscreens.Every individual gets at most only one chance to grow old. When you experience your body falling apart, it is easy to imagine that this is just due to the fact that you are advancing in age. I think the best way to characterize statin therapy is that it makes you grow older faster. Mobility is a great miracle that cholesterol has enabled in all animals. By suppressing cholesterol synthesis, statin drugs can destroy that mobility. No study has shown that statins improve all-cause mortality statistics. But there can be no doubt that statins will make your remaining days on earth a lot less pleasant than they would otherwise be.
To optimize the quality of your life, increase your life expectancy, and avoid heart disease, my advice is simple: spend significant time outdoors; eat healthy, cholesterol-enriched, animal-based foods like eggs, liver, and oysters; eat fermented foods like yogurt and sour cream; eat foods rich in sulfur like onions and garlic. And finally, say “no, thank-you” to your doctor when he recommends statin therapy. K.D. Brandt, P. Dieppe, E. Radin, “Etiopathogenesis of osteoarthritis”. Med. Clin. North Am. 93 (1): 1???24, 2009.
 J. Cable, “Adverse Events of Statins – An Informal Internet-based Study,” JOIMR, 7(1), 2009.
 S. Calaghan, “Caveolae as key regulators of cardiac myocyte beta2 adrenoceptor signalling: a novel target for statins” Research Symposium on Caveolae: Essential Signalosomes for the Cardiovascular System, Proc Physiol Soc 19, SA21, University of Manchester, 2010.
 K.S. Collison, S.M. Saleh, R.H. Bakheet, R.K. Al-Rabiah, A.L. Inglis, N.J. Makhoul, Z.M. Maqbool, M. Zia Zaidi, M.A. Al-Johi and F.A. Al-Mohanna, “Diabetes of the Liver: The Link Between Nonalcoholic Fatty Liver Disease and HFCS-55” Obesity, 17(11), 2003-2013, Nov. 2009.
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 O. Feron, C. Dessy, J.-P. Desager, andJ.-L. Balligand, “Hydroxy-Metholglutaryl-Coenzyme A Reductase Inhibition Promotes Endothelial Nitric Oxide Synthase Activation Through a Decrease in Caveolin Abundance,” Circulation 103, 113-118, 2001.
 M.R. Goldstein and L. Mascitelli, “Statin-induced diabetes: perhaps, its the tip of the iceberg,” QJM, Published online, Nov 30, 2010.
 S.S. Gottlieb, M. Khatta, and M.L. Fisher. “Coenzyme Q10 and congestive heart failure.” Ann Intern Med, 133(9):745???6, 2000.
 J.-P. Gratton, P. Bernatchez, and W.C. Sessa, “Caveolae and Caveolins in the Cardiovascular System,” Circulation Research, 94:1408-1417, June 11, 2004.
 D.S. Grimes, E. Hindle and T. Dyer, “Sunlight, Cholesterol and Coronary Heart Disease,” Q. J. Med 89, 579-589, 1996; http://www.ncbi.nlm.nih.gov/pubmed/8935479
 J. Hagedorn and R. Arora, “Association of Statins and Diabetes Mellitus,” American Journal of Therapeutics, 17(2):e52, 2010.
 T.H. Haines, “Do Sterols Reduce Proton and Sodium Leaks through Lipid Bilayers?” Progress in Lipid Research, 40, 299-324., 2001; http://www.ncbi.nlm.nih.gov/pubmed/11412894
 T. Kikuchi, N. Oka, A. Koga, H. Miyazaki, H. Ohmura, and T. Imaizumi, “Behavior of Caveolae and Caveolin-3 During the Development of Myocyte Hypertrophy,” J Cardiovasc Pharmacol. 45:3, 204-210, March 2005.
 P.H. Langsjoen and A.M. Langsjoen, “The clinical use of HMG CoA-reductase inhibitors and the associated depletion of coenzyme Q10. A review of animal and human publications.” Biofactors, 18(1):101???111, 2003.
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 J. Liu, A. Li and S. Seneff, “Automatic Drug Side Effect Discovery from Online Patient-Submitted Reviews: Focus on Statin Drugs.” Submitted to First International Conference on Advances in Information Mining and Management (IMMM) Jul 17-22, 2011, Bournemouth, UK.
 A. Maguy, T.E. Hebert, and S. Nattel, “Involvement of Lipid rafts and Caveolae in cardiac ion channel function,” Cardiovascular Research, 69, 798-807, 2006.
 B.M. Meador and K.A. Huey, “Statin-Associated Myopathy and its Exacerbation with Exercise,” Muscle and Nerve, 469-79, Oct. 2010.
 C. Minetti, F. Sotgia, C. Bruno, et al., “Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy,” Nat. Genet., 18, 365-368, 1998.
 O.B. Nielsen, F. de Paoli, and K. Overgaard, “Protective effects of lactic acid on force production in rat skeletal muscles.” J. Phhsiology 536(1), 161-166, 2001.
 P.S. Phillips, R.H. Haas, S. Bannykh, S. Hathaway, N.L. Gray, B.J. Kimura, G. D. Vladutiu, and J.D.F. England. “Statin-associated myopathy with normal creatine kinase levels,” Ann Intern Med, October 1, 2002;137:581???5.
 G. de Pinieux, P. Chariot, M. Ammi-Said, F. Louarn, J.L. LeJonc, A. Astier, B. Jacotot, and R. Gherardi, “Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reducase inhibitors on serum ubiquinone and blood lactate/pyruvate ratios.” Br. J. Clin. Pharmacol. 42: 333-337, 1996.
 R.A. Robergs, F. Ghiasvand, and D. Parker, “Biochemistry of exercise-induced metabolic acidosis.” Am J Physiol Regul Integr Comp Physiol 287: R502???R516, 2004.
 G. Saher, B. Br??gger, C. Lappe-Siefke, et al. “High cholesterol level is essential for myelin membrane growth.” Nat Neurosci 8:468-75, 2005.
 S. Seneff, G. Wainwright, and L. Mascitelli, “Is the Metabolic Syndrome Caused by a High Fructose, and Relatively Low Fat, Low Cholesterol Diet?” Archives of Medical Science, 7(1), 8-20, 2011; DOI: 10.5114/aoms.2011.20598
 S. Seneff, G. Wainwright, and L. Mascitelli, “Nutrition and Alzheimer’s Disease: the Detrimental Role of a High Carbohydrate Diet,” In Press, European Journal of Internal Medicine, 2011.
 S. Seneff, G. Wainwright and B. Hammarskjold, “Cholesterol Sulfate Supports Glucose and Oxygen Transport into Erythrocytes and Myocytes: a Novel Evidence Based Theory,” submitted to Hypotheses in the Life Sciences.
 S. Seneff, G. Wainwright and B. Hammarskjold, “Atherosclerosis may Play a Pivotal Role in Protecting the Myocardium in a Vulnerable Situation,” submitted to Hypotheses in the Life Sciences.
 H. Sinzinger and J. O???Grady, “Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscle problems.” Br J Clin Pharmacol 57,525-528, 2004.
 E.J. Smart, G.A. Graf, M.A. McNiven, W.C. Sessa, J.A. Engelman, P.E. Scherer, T. Okamoto, and M.P. Lisanti, “Caveolins, Liquid-Ordered Domains, and Signal Transduction,” Molecular and Cellular Biology, 19, 7289???7304, Nov. 1999.
 A.J. Shyam Kumar, S.K. Wong, and G. Andrew, “Statin-induced muscular symptoms : A report of 3 cases.” Acta Orthop. Belg. 74, 569-572, 2008.
 M.A. Silver, P.H. Langsjoen, S. Szabo, H. Patil, and A. Zelinger, “Effect of atorvastatin on left ventricular diastolic function and ability of coenzyme Q10 to reverse that dysfunction.” The American Journal of Cardiology, 94(10):1306???1310, 2004.
 Y. Sunada, H. Ohi, A. Hase, H. Ohi, T. Hosono, S. Arata, S. Higuchi, K. Matsumura, and T. Shimizu, “Transgenic mice expressing mutant caveolin-3 show severe myopathy associated with increased nNOS activity,” Human Molecular Genetics 10(3) 173-178, 2001. http://hmg.oxfordjournals.org/content/10/3/173.abstract
 M. J. Taggart, “The complexity of caveolae: a critical appraisal of their role in vascular function,” Research Symposium on Caveolae: Essential Signalosomes for the Cardiovascular System, Proc Physiol Soc 19, SA21, University of Manchester, 2010.
 P. Thavendiranathan, A.Bagai, M.A. Brookhart, and N.K. Choudhry, “Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials,” Arch Intern Med. 166(21), 2307-13., Nov 27, 2006.
 R.S. Tilvis, J.N. Valvanne, T.E. Strandberg and T.A. Miettinen “Prognostic significance of serum cholesterol, lathosterol, and sitosterol in old age; a 17-year population study,” Annals of Medicine, Early Online, 1???10, 2011.
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 K.A. Weant and K.M. Smith, “The Role of Coenzyme Q10 in Heart Failure,” Ann Pharmacother, 39(9), 1522-6, Sep. 2005.
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- ??? 2011(14)
- ??? March(14)
- How Statins Really Work Explains Why They Don’t Re…
- 2. Cholesterol and Statins
- 3. LDL, HDL, and Fructose
- 4. How Statins Destroy Muscles
- Table 1: Statins and Muscle Damage
- 5. Membrane Cholesterol Depletion and Ion Transpor…
- 6. Long-term Statin Therapy Leads to Damage Everyw…
- Table 2: Statistics on Statins and Other Major Hea…
- 7. Statins, Caveolin, and Muscular Dystrophy
- 8. Statins and the Brain
- 9. Cholesterol’s Benefits to Longevity
- 10. What to do Instead to Avoid Heart Disease
- 11. Concluding Remarks
- References for “Why Statins Don’t Really Work”
- ??? 2010(27)
- ??? September(12)
- Could Sulfur Deficiency be a Contributing Factor i…
- 2. Sulfur Availability and Obesity Rates
- 3. Why Does Sulfur Deficiency Lead to Obesity?
- 4. Sulfur and Glucose Metabolism
- 5. The Metabolc Syndrome
- 6. Fat Cells, Macrophages and Atherosclerosis
- 7. Sulfur and Alzheimer’s
- 8. Is The Skin a Solar-Powered Battery for the He…
- 9. Sulfur Deficiency and Muscle Wasting Diseases
- 9. Sulfur Deficiency and Muscle Wasting Diseases
- 10. Summary
- References for Sulfur Essay
- ??? February(15)
- Statins and Myoglobin: How Muscle Pain and Weaknes…
- 2. The Biological Mechanism of Statin Drugs
- 3. Statins, Muscle Pain and Weakness, and Rhabdomy…
- 4. How Muscles Maintain their Energy Supply
- 5. Managing Energy Needs During Extreme Exercise
- 6. Extreme Exercise can lead to Rhabdomyolysis
- 7. Myoglobin: The Good, The Bad, and the Ugly
- 8. How Cholesterol Protects Membranes and Saves En…
- 9. The Evidence of Statin Damage to Muscles
- 10. Statins and Heart Failure
- 11. Statins and Lung Disease
- 12. Statins and Diabetes
- 13. Statins and Muscle Damage: Conclusions
- Acknowledgements for Essay on Statins and Muscle D…
- References for Essay on Statins and Muscle Damage
- ??? 2009(66)
- ??? December(18)
- APOE-4: The Clue to Why Low Fat Diet and Statins m…
- 1. Introduction to Alzheimer’s Essay
- 2. Background: Brain Biology 101
- 3. Cholesterol and Lipid Management
- 4. The Relationship between Cholesterol and Alzhei…
- 5. Do Statins Cause Alzheimer’s?
- 6. Astrocytes, Glucose Metabolism, and Oxygen
- 7. The Crucial Role of Amyloid-Beta
- 8. Cholesterol’s Role in the Brain